Primary splenic CD8-positive diffuse large B-cell lymphoma

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Other Title
  • 脾臓に原発したCD8陽性びまん性大細胞型B細胞性悪性リンパ腫
  • 症例 脾臓に原発したCD8陽性びまん性大細胞型B細胞性悪性リンパ腫
  • ショウレイ ヒゾウ ニ ゲンパツ シタ CD8 ヨウセイビマンセイ ダイ サイボウガタ B サイボウセイ アクセイ リンパ シュ

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Abstract

A 71-year-old woman was admitted for further examination of an increased serum LDH level. Abdominal ultrasonography and CT scan showed a large tumor in her spleen. Because malignant lymphoma was suspected, the spleen was removed for diagnosis and treatment planning. The histopathological and immunohistochemical features of the tumor indicated diffuse large B-cell lymphoma (DLBL). The flow-cytometric immunophenotype of the lymphoma cells was CD2-, CD3-, CD4-, CD5-, CD8+, CD10+, CD19+, CD20+, CD23-, κ+, λ-, CD25+, and CD56-. From these findings, the patient was diagnosed as having CD8+ DLBL. To our knowledge, this is the first reported case of primary splenic CD8-positive DLBL.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 42 (12), 1187-1191, 2001

    The Japanese Society of Hematology

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