Comparison of Isoflavones Among Dietary Intake, Plasma Concentration and Urinary Excretion for Accurate Estimation of Phytoestrogen Intake

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著者

    • ARAI Yusuke
    • Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
    • UEHARA Mariko
    • Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
    • SATO Yuho
    • Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
    • KIMIRA Mitsuru
    • Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
    • EBOSHIDA Akira
    • Department of Life Science, Scienal and Technology Agency of Japan
    • ADLERCREUTZ Herman
    • Institute for Preventive Medicine, Nutrition and Cancer, Folkhalsan Research Center and Department of Clinical Chemistry, University of Helsinki
    • WATANABE Shaw
    • Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

抄録

Biological effects of dietary isoflavones, such as daidzein and genistein are of interest in preventive medicine. We estimated the dietary intake of isoflavones from dietary records and compared the values with the plasma concentrations and urinary excretions in Japanese middleaged women. The dietary intake of daidzein and genistein was 64.6 and 111.6μ mol/day/capita (16.4 and 30.1 mg/day/capita), respectively. The isoflavones intake was mostly attributable to tofu, natto and miso. The median of plasma daidzein and genistein concentration was 72.46 and 206.09 nmol/L, respectively. The median of urinary excretion was 20.54μ mol/day for daidzein, 10.79 for genistein, 15.74 for equol and 1.64 for O-desmethylangolensin (0-DMA). Equol and 0DMA were excreted by 50 % and 84 % of all participants, respectively. Equol metabolizers were significantly lower the plasma and urinary daidzein and urinary O-DMA. The dietary intake of daidzein and genistein after the adjustment for total energy intake was significantly correlated with the urinary excretion (r=0.365 for daidzein and r=0.346 for genistein) and plasma concentration (r=0.335 for daidzein and r=0.429 for genistein). The plasma concentration of isoflavones was also significantly correlated with the urinary excretion. We conclude that in epidemiological studies measurements of plasma concentration or urinary excretion of these isoflavones are useful biomarkers of dietary intake and important for studies on their relation to human health. <i>J Epidemiol</i>, 2000 ; 10 : 127-135

収録刊行物

  • Journal of epidemiology

    Journal of epidemiology 10(2), 127-135, 2000-03

    日本疫学会

参考文献:  30件中 1-30件 を表示

被引用文献:  6件中 1-6件 を表示

各種コード

  • NII論文ID(NAID)
    10013257700
  • NII書誌ID(NCID)
    AA10952696
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09175040
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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