Apolipoprotein E, Methylenetetrahydrofolate Reductase (MTHFR) Mutation and the Risk of Senile Dementia : An Epidemiological Study Using the Polymerase Chain Reaction (PCR) Method

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著者

    • KATO Yukie
    • Department of Legal Medicine, Dokkyo University School of Medicine
    • YUKAWA Satoru
    • Department of Public Health, Dokkyo University School of Medicine
    • OMORI Kenichi
    • Department of Neuropsychiatry, Dokkyo University School of Medicine

抄録

We examined apolipoprotein E (Apo E) polymorphism and methylenetetrahydrofolate reductase (MTHFR) 677 C to T mutation by using the polymerase chain reaction (PCR) method in 100 elderly Japanese aged 60 or more, and assessed whether these genetic factors are associated with an increased risk for the clinical phenotypes of senile dementia, Alzheimer's disease (AD) and vascular dementia (VD) by cross-sectional survey. It was found that the Apo E * 4 allele were associated with an increased prevalence of AD as previously reported. Although, it was not strongly related to the severity of senile dementia, a weak associaton between the ApoE genotype and the severity of dementia was suggested. The proportion of patients with senile dementia was higher in the group of carriers of MTHFR mutation than in the group of noncarriers. Furthermore, the proportion of male patients with senile dementia was higher in the group of homozygous for the mutation (+/+) than the group without the mutation (-/-). Notably in VD patients, 5 of 7 males had the +/+ genotype. The results suggest that the ApoE ε 4 genotype and the MTHFR mutation are associated with the clinical phenotype and the clinical onset of senile dementia. J Epidemiol, 2000 ; 10 : 163-172

収録刊行物

  • Journal of epidemiology

    Journal of epidemiology 10(3), 163-172, 2000-05

    日本疫学会

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各種コード

  • NII論文ID(NAID)
    10013257831
  • NII書誌ID(NCID)
    AA10952696
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09175040
  • データ提供元
    CJP書誌  J-STAGE 
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