The Risk for Second Primaries in Gastric Cancer Patients : Adjuvant Therapy and Habitual Smoking and Drinking

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著者

    • KINOSHITA Yoko
    • Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases
    • TSUKUMA Hideaki
    • Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases
    • AJIKI Wakiko
    • Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases
    • KINOSHITA Noriko
    • Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases
    • OSHIMA Akira
    • Department of Cancer Control and Statistics, Osaka Medical Center for Cancer and Cardiovascular Diseases
    • HIRATSUKA Masahiro
    • Department of Gastroenterological Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases

抄録

Study purpose: To examine whether adjuvant therapy for gastric cancer increases the risk for second primaries, and whether smoking and drinking increase the risk.Subjects and methods: 1, 631 patients who were newly diagnosed with gastric cancer and underwent curative operation at Osaka Medical Center for Cancer and Cardiovascular Diseases during 1978-92. Incidence of second primaries were examined through linkage to Osaka Cancer Registry as of the end of December 1995. Observed number of second primaries (0) was compared with the expected according to the incidence in general population (E). Proportional hazards model was used to estimate hazard rate ratio (HR) for second primaries.Results: 149 second primaries were observed. Seventeen cases, detected within 2 months after diagnosis of gastric cancer, were excluded. O/E ratio was 1.13 for adjuvant chemotherapy, 0.93 for immuno-chemotherapy, and 0.78 for immunotherapy, while 1.14 for operation only (not significant). Age-, sex-, and stage-adjusted HR was 1.02 (95% C.I. 0.69-1.50) for chemotherapy, 0.80 (0.41-1.57) for immuno-chemotherapy, and 0.60 (0.08-4.34) for immunotherapy, as compared with the risk for operation only. Among males, HR for current smokers vs. never smokers was 1.82 (1.02-3.26).Conclusions: Adjuvant therapy for gastric cancer did not significantly increase the risk for second primaries, while smoking elevated it. J Epidemiol, 2000 ; 10 : 300-304

収録刊行物

  • Journal of epidemiology

    Journal of epidemiology 10(5), 300-304, 2000-09

    日本疫学会

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各種コード

  • NII論文ID(NAID)
    10013258220
  • NII書誌ID(NCID)
    AA10952696
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09175040
  • データ提供元
    CJP書誌  J-STAGE 
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