Relationships between Cigarette Smoking, Alcohol Drinking, the ALDH2 Genotype and Adenomatous Types of Colorectal Polyps in Male Self-Defense Force Officials.

DOI Web Site PubMed 参考文献57件
  • Takeshita Tatsuya
    Cancer Information and Epidemiology Division, National Cancer Research Institute
  • Morimoto Kanehisa
    Cancer Information and Epidemiology Division, National Cancer Research Institute
  • Yamaguchi Naohito
    Cancer Information and Epidemiology Division, National Cancer Research Institute
  • Watanabe Shaw
    Deparment of Applied Bioscience, Tocky University of Agriculture
  • Todoroki Isao
    Deparment od Public Health, National Defense Medical College, Tokorozawa
  • Honjo Satoshi
    Deparment od Public Health, National Defense Medical College, Tokorozawa
  • Nakagawa Katsuya
    Self-Defense Forces Central Hospital
  • Kono Suminori
    Deparment of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka

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Alcohol drinking as well as cigarette smoking has been associated with development of colorectal polyps. Asians such as Japanese, Chinese and Korean have high frequency of genetic polymorphism in low Km aldehyde dehydrogenase (ALDH2) gene which greatly regulates alcohol intake. In the present study, we investigated associations of this polymorphism and lifestyles with colorectal polyps in self-defense forces personnels in Japan. All subjects received colonoscopy at a retirement health examination. The ALDH2 genotype was determined using polymerase chain reaction and restriction fragment length polymorphism method. Frequency of the ALDH2 genotype was not different between those with colorectal polyps (n=69) and those without the polyps (n=131). Smoking was associated with development of colorectal polyps (OR=4.7, 95% confidence interval= 1.9-11.5) in the ALDH2 proficient genotype. The association appeared to be enhanced by drinking alcohol since a synergistic effect of smoking and alcohol drinking (>_60 ml/day) was indicated (OR=9.9, 95% confidence interval=2.9-34.1) by logistic regression analysis. In the ALDH2 deficient genotype, however, we could not evaluate interactions of smoking and alcohol drinking on colorectal polyp development because of the small sample size of heavy alcohol drinkers. The genotype analysis would be useful in evaluating effects of environmental factors on outcomes for each genetically defined subpopulation.<br> J Epidemiol, 2000 ; 10 : 366-371

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