Technetium-99m Tetrofosmin Parathyroid Imaging in Patients with Primary Hyperparathyroidism

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<i>Objective</i> To confirm the clinical significance of <sup>99m</sup>Tc-tetrofosmin imaging for the localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism.<br> <i>Methods</i> All patients were imaged with <sup>99m</sup>Tc-tetrofosmin at 10 minutes and 2 hours after radiotracer injection, and with ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI). The parathyroid/thyroid uptake ratio of <sup>99m</sup>Tc-tetrofosmin (P/T uptake ratio) was calculated.<br> <i>Patients</i> Twenty patients with primary hyperparathyroidism were referred to our clinic, underwent surgical neck exploration or mediastinotomy and were diagnosed as having parathyroid adenoma. These patients were investigated for the preoperative localization by <sup>99m</sup>Tc-tetrofosmin scintigraphy.<br> <i>Results</i> <sup>99m</sup>Tc-tetrofosmin imaging demonstrated focal uptake in 19 out of 20 patients with parathyroid adenoma. Two of the lesions were ectopic. US identified 17 parathyroid glands. CT and MRI initially detected 17 parathyroid glands. However, two additional parathyroid glands were localized on repeated CT and MRI in tandem with the results of the <sup>99m</sup>Tc-tetrofosmin imaging. Thus, the sensitivity and specificity of tetrofosmin imaging were 95% (19/20) and 95% (19/20); US, 85% (17/20) and 94% (16/17); initial CT, 85% (17/20) and 94% (16/17); and initial MRI, 88% (17/20) and 94% (16/17), respectively. The P/T uptake ratio at 2 hours after tetrofosmin injection was correlated with the serum concentration of intact PTH (rs=0.47, p<0.05) and the resected tumor weight (rs=0.53, p<0.05).<br> <i>Conclusion</i> <sup>99m</sup>Tc-tetrofosmin scintigraphy is useful for localization of parathyroid adenoma. Tetrofosmin uptake depends on the tumor weight and serum intact PTH levels.<br>(Internal Medicine 39: 101-106, 2000)

収録刊行物

  • Internal medicine

    Internal medicine 39(2), 101-106, 2000-02-01

    一般社団法人 日本内科学会

参考文献:  36件中 1-36件 を表示

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各種コード

  • NII論文ID(NAID)
    10013261356
  • NII書誌ID(NCID)
    AA10827774
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09182918
  • NDL 記事登録ID
    5296465
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z53-M398
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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