Antibody-mediated Insulin Resistance Treated by Cessation of Insulin Administration

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A 45-year-old Japanese man was referred to our hospital because of hyperglycemia despite the administration of as much as 120 U/day of human insulin. He had no history of injecting animal insulin. Free insulin was below 5 μU/ml, but a high liter of total insulin (about 3, 000 μU/ml) was observed, suggesting the presence of antibodies against human insulin. Scatchard analysis showed an increased insulin binding capacity in the plasma characterized by a higher affinity for insulin. He was successfully treated by cessation of insulin administration. A Scatchard analysis series showed that a reduction in the insulin binding capacity of antibodies paralleled the improvement in glycemic control.<br>(Internal Medicine 39: 143-145, 2000)

収録刊行物

  • Internal medicine

    Internal medicine 39(2), 143-145, 2000-02-01

    一般社団法人 日本内科学会

参考文献:  9件中 1-9件 を表示

被引用文献:  5件中 1-5件 を表示

各種コード

  • NII論文ID(NAID)
    10013261587
  • NII書誌ID(NCID)
    AA10827774
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    09182918
  • NDL 記事登録ID
    5296565
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z53-M398
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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