Hyperprolactinemia in Optico-spinal Multiple Sclerosis

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著者

    • OSOEGAWA Manabu
    • Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    • KAWANO Yuji
    • Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    • OHYAGI Yasumasa
    • Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    • YAMADA Takeshi
    • Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    • KIRA Jun-ichi
    • Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University

抄録

<i>Objective</i> To clarify the clinical features of MS patients with hyperprolactinemia.<br> <i>Subjects and Methods</i> The serum prolactin level was measured in 67 Japanese patients (19 men and 48 women) with multiple sclerosis (MS) and in 16 patients (4 men and 12 women) with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) using a two-site immunoradiometric assay.<br> <i>Results</i> In the MS patients, 32 were classified as having Asian type MS showing a selective involvement of the optic nerves and spinal cord, while the other 35 were classified as having Western type MS which displayed disseminated central nervous system involvement. In women, the serum prolactin level was found to be significantly higher only in Asian type MS (mean=23.1 ng/ml, n=25) than in HAM/TSP (mean=6.9 ng/ml, n=12) (p=0.0297), while it did not differ significantly in men among the three groups. Hyperprolactinemia was significantly associated with acute relapse involving the optic nerves. All MS patients with hyperprolactinemia (7 women with Asian type MS and 2 women with Western type MS) showed recurrent opticomyelitis either throughout or in the early course of the disease, and also had a higher age of onset, a higher Expanded Disability Status Scale score, a greater visual impairment, and higher cell counts and protein contents in the cerebrospinal fluid than did the normoprolactinemic patients.<br> <i>Conclusion</i> Hyperprolactinemia may be one of the characteristic features of Asian patients with MS who preferentially show the optic nerve involvement.<br>(Internal Medicine 39: 296-299, 2000)

収録刊行物

  • Internal medicine

    Internal medicine 39(4), 296-299, 2000-04-01

    The Japanese Society of Internal Medicine

参考文献:  17件中 1-17件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10013261901
  • NII書誌ID(NCID)
    AA10827774
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09182918
  • NDL 記事登録ID
    5371404
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z53-M398
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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