Possible Risk Factors of Carotid Artery Atherosclerosis in the Japanese Population : A Primary Prevention Study in Non-diabetic Subjects

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<i>Objective</i> Hyperinsulinemia has been associated with the risk of coronary heart disease, stroke, and renal disease in nondiabetic subjects. However, direct evidence that hyperinsulinemia per se is directly associated with atherosclerosis has been conflicting. The present study was designed to investigate the cross-sectional association of carotid artery atherosclerosis with insulin, independent of well-known cardiovascular risk factors, in nondiabetic subjects.<br> <i>Methods and Subjects</i> Between 1996 and 1997, 1, 335 subjects (620 men and 715 women) were recruited from one Japanese community, interviewed, and examined. Clinical measurements in the study included intimal-medial thickness (IMT) of the carotid artery, fasting plasma insulin, serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), hemoglobin type HbA<sub>1c</sub>, systolic blood pressure (SBP), diastolic blood pressure (DBF), and body mass index (BMI). We divided the subjects of both genders into three subgroups according to age (40-49 years of age; 50-59; and 60-69).<br> <i>Results</i> Using simple regression analysis, we found that IMT was significantly correlated with at least one of TC, LDL-C, HbA<sub>1c</sub>, SBP, DBF, and BMI in each subgroup. The results of multivariate analysis showed that IMT was independently correlated with TC, HDL-C, LDL-C, SBP and BMI in males and with TC, TG, HDL-C, LDL-C, HbA<sub>1c</sub>, SBP, DBF, and BMI in females. Insulin levels showed no correlation with IMT in either males or females.<br> <i>Conclusion</i> Fasting hyperinsulinemia does not appear to be correlated with carotid artery atherosclerosis based on the present cross-sectional results.<br>(Internal Medicine 39: 362-368, 2000)

収録刊行物

  • Internal medicine

    Internal medicine 39(5), 362-368, 2000-05-01

    一般社団法人 日本内科学会

参考文献:  42件中 1-42件 を表示

被引用文献:  8件中 1-8件 を表示

各種コード

  • NII論文ID(NAID)
    10013262203
  • NII書誌ID(NCID)
    AA10827774
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09182918
  • NDL 記事登録ID
    5384338
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z53-M398
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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