Mitochondrial DNA and Human Thyroid Diseases

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著者

    • ROGOUNOVITCH TATIANA
    • Department of Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University
    • SAENKO VLADIMIR
    • Department of International Health and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University
    • YAMASHITA SHUNICHI
    • Department of Molecular Medicine, Graduate School of Biomedical Sciences, Nagasaki University

抄録

Cells of the thyroid tissue, either diseased or normal, can accumulate altered mitochondrial genomes in primary lesions and in surrounding parenchyma. Depending on the experimental approaches and the extent of the mutational process, it has been possible to demonstrate the occurrence of homoplasmic or heteroplasmic point mutations, presence of a common deletion and random large-scale mtDNA aberrations in various pathological states. Point somatic mutations documented in 5-60% of thyroid tumors do not concentrate in obvious hotspots but tend to cluster in certain regions of the mitochondrial genome and their distribution may differ between carcinomas and controls. Large-scale deletions in mtDNA are quite prevalent in healthy and diseased thyroid; however, the proportion of aberrant mtDNA molecules accounts for a very small part of total mtDNA and does not seem to correlate with pathological characteristics of thyroid tumors. Common deletion is most abundant in Hurthle cell tumors, yet it also occurs in other thyroid diseases as well as in normal tissue. The principal difference between the common deletion and other deletion-type mtDNA molecules is that the former does not depend on the relative mtDNA content in the tissue whereas in a subset of thyroid tumors, such as radiation-associated papillary carcinomas and follicular adenomas, there is a strong correlation between mtDNA levels and prevalence of large-scale deletions. Relative mtDNA levels by themselves are elevated in most thyroid tumors compared to normal tissue. Distinct differential distribution and prevalence of mutational mtDNA burden in normal tissue and thyroid lesions are suggestive of the implication of altered mtDNA in thyroid diseases, especially in cancer.<br>

収録刊行物

  • Endocrine journal

    Endocrine journal 51(3), 265-277, 2004-06-01

    一般社団法人 日本内分泌学会

参考文献:  95件中 1-95件 を表示

被引用文献:  1件中 1-1件 を表示

各種コード

  • NII論文ID(NAID)
    10013292697
  • NII書誌ID(NCID)
    AA10901436
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    09188959
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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