Weekly Paclitaxel in Pretreated Metastatic Breast Cancer : Retrospective Analysis of 52 Patients

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著者

    • BALTALI ESMEN
    • Hacettepe University Faculty of Medicine Department of Medical Oncology
    • ALTUNDAG KADRI
    • Hacettepe University Faculty of Medicine Department of Medical Oncology
    • OZISIK YAVUZ
    • Hacettepe University Faculty of Medicine Department of Medical Oncology
    • GULER NILUFER
    • Hacettepe University Faculty of Medicine Department of Medical Oncology
    • TEKUZMAN GULTEN
    • Hacettepe University Faculty of Medicine Department of Medical Oncology

抄録

Single-agent paclitaxel has been shown to be effective as both first- and second-line treatment of metastatic breast cancer, and the efficacy and tolerability of weekly administration of paclitaxel has generated much interest. Fifty-two patients with pretreated metastatic breast cancer who were admitted to Hacettepe University between January 2001 and June 2002 were retrospectively analyzed in this study. Paclitaxel was administered weekly in a dose of 80 mg/m<sup>2</sup> over 1 hour. The median number of cycles delivered was 20 weeks (range, 8 to 24). The median delivered dose was 2400 mg (range, 960 to 3840 mg). At a median follow-up of 12.3 months (range, 6 to 17), all patients were assessable for response and toxicity. A complete response and partial response were observed in 7 (13.5%), and 19 (36.5%) patients, respectively. Overall response rate was 50%. Median duration of response was 10 months (range, 3 to 16). Therapy was generally well tolerated, and toxicities were manageable. Severe leukopenia was seen in two (4%) patients. Based on these results, we conclude that weekly paclitaxel is a well-tolerated and highly effective regimen in pre-treated metastatic breast cancer.

収録刊行物

  • THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

    THE TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 203(3), 205-210, 2004-07-01

    東北ジャーナル刊行会

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各種コード

  • NII論文ID(NAID)
    10013299249
  • NII書誌ID(NCID)
    AA00863920
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00408727
  • データ提供元
    CJP書誌  J-STAGE 
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