顕微鏡観察下における局所的温度制御のためのマイクロデバイス Micro Device for Local Temperature Control under Microscope
The device for controlling the temperature locally under a microscope in a short response time, within 3 seconds, is developed. This device is equipped with a temperature controlling micro heater and a micro thermo sensor patterned on a glass plate which can be used for general biochemical assay. Since this device controls the temperature so locally, the total amount of the heat which is needed for temperature controlling is small enough to avoid the negative effects such as defocusing during observation under a microscope. We established the sensor model to calculate the temperature from the measured resistance value and the initial resistance at the roon temperature. Thus, we can avoid the calibration in each sensor. The rotation velocity change of a single F1 molecule, the rotary biomolecular motor, within short response time is successfully observed by controlling the temperature. This is the result that could not be achieved without MEMS technology. This result also shows the applicability of the device to other temperature controlling biochemical assay.
- 電気学会論文誌. E, センサ・マイクロマシン準部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A publication of Sensors and Micromachines Society
電気学会論文誌. E, センサ・マイクロマシン準部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A publication of Sensors and Micromachines Society 124(8), 284-288, 2004-08-01