難治性中耳炎初発のウェゲナー肉芽腫症例 Wegener's Granulomatosis of the Ear : Case Report

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Wegener's granulomatosis is a rare autoimmune disease affecting predominantly the nose or paranasal sinuses. Other organs of the upper air way may, however, be involved either alone or as parts of generalized disease. Occasionally the otological manifestation is the first and only sign of Wegener's granulomatosis.<br>In this case report we describe Wegener's granulomatosis in a 43-year-old female who complained of right aural discharge. Treatment for otitis media with systemic antibiotics was not effective, and due to persistent headache accompanied by mixed hearing loss, mastoidectomy was performed two months after the initial presentation. Histological examinations revealed granulomatous tissue in the mastoid, showing non-specific granulomatous inflammation. After operation, she developed painful gingival swelling and nasal obstruction. Finally, the patient was diagnosed with Wegener's granulomatosis based on the clinical, histological, and laboratory findings.<br>Since it is often difficult to confirm the diagnosis histologically, especially in limited types of Wegener's granulomatosis, we consider it better to rely on a test for C-ANCA when positive histological findings are not observed in the biopsy specimens.<br>The diagnosis should be considered in patients with otitis media that are unresponsive to conventional treatment.

収録刊行物

  • 耳鼻咽喉科臨床

    耳鼻咽喉科臨床 97(8), 691-695, 2004-08-01

    耳鼻咽喉科臨床学会

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各種コード

  • NII論文ID(NAID)
    10013353650
  • NII書誌ID(NCID)
    AN00107089
  • 本文言語コード
    JPN
  • 資料種別
    NOT
  • ISSN
    00326313
  • NDL 記事登録ID
    7053574
  • NDL 雑誌分類
    ZS43(科学技術--医学--耳鼻咽喉科学)
  • NDL 請求記号
    Z19-421
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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