Ascending pain-related pathways to the anterior cingulate cortex : retrograde transneuronal tracing with rabies virus

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著者

    • IWATA Koichi
    • Department of Physiology, Nihon University, School of Dentistry
    • MIYACHI Shigehiro
    • Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience
    • IMANISHI Michiko
    • Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience
    • TERAMOTO Kohei
    • Department of Physiology, Nihon University, School of Dentistry
    • TAKADA Masahiko
    • Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience

抄録

   The organization of ascending pain-related projections to the anterior cingulate cortex was examined in the rat by means of retrograde transneuronal labeling with rabies virus. Three days after the virus injection into the anterior cingulate cortex, a large number of labeled neurons were observed in the thalamus (i.e., the parafascicular and centrolateral nuclei) and the limbic-related structures (i.e., the orbital cortex and the basolateral amygdaloid nucleus). The neuronal labeling in these regions became much more intense four days after the virus injection. At the four-day post injection period, the submedius nucleus of the thalamus also contained many labeled neurons. In addition, retrograde labeling simultaneously occurred in the brainstem regions, such as the parabrachial nuclei and the caudal division of the spinal trigeminal nucleus. At the same timing or a little later stage, labeled neurons were seen in the trigeminal ganglion. The present results suggest that the ascending pathways linking the trigeminal ganglion and the anterior cingulate cortex may play important roles in the processing of noxious information in association with the emotional aspect of pain.

収録刊行物

  • Pain research : the journal of the Japanese Society for the Study of Pain = 日本疼痛学会誌

    Pain research : the journal of the Japanese Society for the Study of Pain = 日本疼痛学会誌 19(3), 85-90, 2004-07-31

    日本疼痛学会

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各種コード

  • NII論文ID(NAID)
    10013355194
  • NII書誌ID(NCID)
    AN10195934
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09158588
  • データ提供元
    CJP書誌  J-STAGE 
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