Kinetic Analysis of Water Transfer through Stratum Corneum by a Ventilated Chamber Measurement System

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For a detailed analysis of the water barrier function of skin, it is necessary to obtain effective physical parameters related to the rate of transepidermal water loss (TEWL). By using a modified ventilated chamber measurement system, with high sensitivity and response, we have determined the apparent mass transfer coefficient of water, <I>K</I>, for the stratum corneum (SC) and the water vapor pressure, <I>P</I><SUB>d</SUB>, at the interface between SC and underlying living cells of epidermis from analyses of water distribution in the contact zone of carrier gas and skin surface. By data fit optimization of the calculated water flux to the measured one, the <I>in vivo K</I> value for human skin was determined to be (0.30 ± 0.14) × 10<SUP>–8</SUP> kg/(m<SUP>2</SUP>·s·Pa) (<I>n</I> = 4, mean ± SD) which is close to the corresponding <I>in vitro</I> value of (0.12 ± 0.02) × 10<SUP>–8</SUP> kg/(m<SUP>2</SUP>·s·Pa) (<I>n</I> = 6, mean ± SD) for porcine SC membranes. It is, therefore, concluded that the apparent mass transfer coefficient of water for SC can be estimated <I>in vivo</I> and noninvasively by the method developed in this study and will lead to a more precise and reliable evaluation of skin barrier function than the rate of TEWL itself.

収録刊行物

  • Journal of chemical engineering of Japan

    Journal of chemical engineering of Japan 36(2), 138-146, 2003-02-01

    公益社団法人 化学工学会

参考文献:  28件中 1-28件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10013412138
  • NII書誌ID(NCID)
    AA00709658
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00219592
  • NDL 記事登録ID
    6452163
  • NDL 雑誌分類
    ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-R395
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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