Preparation Characteristics of Lipid Microspheres Using Microchannel Emulsification and Solvent Evaporation Methods
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- Kobayashi Isao
- National Food Research Institute Institute of Agricultural and Forest Engineering, University of Tsukuba
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- Iitaka Yosuke
- National Food Research Institute Department of Environmental Chemical Engineering, Kogakuin University
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- Iwamoto Satoshi
- National Food Research Institute
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- Kimura Shoji
- Department of Environmental Chemical Engineering, Kogakuin University
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- Nakajima Mitsutoshi
- National Food Research Institute Institute of Agricultural and Forest Engineering, University of Tsukuba
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Using a novel microchannel (MC) emulsification method, we are able to form microspheres (MS) with narrow size distributions. MC emulsification and subsequent solvent evaporation were performed to prepare micron-scale lipid MS with relatively narrow size distributions. The experimental systems with hexane as the dispersed-phase solvent stably formed oil-in-water (O/W)-MS with average diameters of 10–11 μm and coefficients of variation below 8% from the uniformly sized channels. The sodium dodecyl sulfate- and pentaglycerol monolaurate-containing systems performed the successful MC emulsification. Lipid MS with average diameters of 1–3 μm and coefficients of variation of about 20% were obtained through successive solvent evaporation of the formed monodisperse O/W-MS composed of 0.1–1.0 vol% tripalmitin in hexane. The diameters of the resultant lipid MS corresponded well to their estimated diameters, regardless of the tripalmitin concentration.
収録刊行物
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- JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
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JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 36 (8), 996-1000, 2003
公益社団法人 化学工学会
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詳細情報 詳細情報について
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- CRID
- 1390001204568879616
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- NII論文ID
- 10013414213
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- NII書誌ID
- AA00709658
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- COI
- 1:CAS:528:DC%2BD3sXntV2qt7k%3D
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- ISSN
- 18811299
- 00219592
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- NDL書誌ID
- 6654173
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 使用不可