Diels-Alderase, a Novel C-C Bond Formation Enzyme Involving Natural Products Biosynthesis

• Oikawa Hideaki

  Division of Chemistry, Graduate School of Science, Hokkaido University

Bibliographic Information

Other Title

• 天然物生合成に関与する新規炭素炭素結合形成酵素Ｄｉｅｌｓ‐Ａｌｄｅｒａｓｅ
• テンネンブツ セイゴウセイ ニ カンヨ スル シンキ タンソ タンソ ケツゴウ ケイセイ コウソ Diels Alderase

Abstract

Recent studies on the enzyme catalyzing Diels-Alder reaction, “Diels-Alderase”, clearly demonstrated involvement of this synthetically useful reaction in the biosynthesis of natural products. This article describes natural Diels-Alder type cycloadducts, synthetic efforts on chemical feasibility of biosynthetic Diels-Alder reaction and brief history of studies on Diels-Alderase. In addition, reaction mechanisms of artificial and natural Diels-Alderase are discussed.

Journal

• Journal of Synthetic Organic Chemistry, Japan

  Journal of Synthetic Organic Chemistry, Japan 62 (8), 778-789, 2004

  The Society of Synthetic Organic Chemistry, Japan

Keywords

• Diels-Alder reaction
• Diels-Alderase
• natural [4+2] adducts
• biomimetic synthesis
• solanapyrone synthase
• lovastatin nonaketide synthase
• macrohomate synthase

Details

• CRID: 1390001205312019456
• NII Article ID: 10013430475
• NII Book ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.62.778
• COI: 1:CAS:528:DC%2BD2cXmvV2jsb4%3D
• ISSN: 18836526
• ISSN: 00379980
• NDL BIB ID: 7060697
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7060697
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed