Noncovalent Combination of Oligoamine and Oligonucleotide as Totally Organic Site-selective RNA Cutter

DOI PDF 参考文献39件
  • Yun Shi
    Research Center for Advanced Science and Technology, The University of Tokyo
  • Fumiya Niikura
    Research Center for Advanced Science and Technology, The University of Tokyo
  • Akinori Kuzuya
    Research Center for Advanced Science and Technology, The University of Tokyo
  • Makoto Komiyama
    Research Center for Advanced Science and Technology, The University of Tokyo

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<jats:title>Abstract</jats:title> <jats:p>When a one-base gap was formed in substrate RNA by using two oligonucleotides, the phosphodiester linkage at the gap-site was activated and selectively hydrolyzed by ethylenediamine. This site-selective hydrolysis was further promoted by connecting two gap-forming oligonucleotides with 1,3-propanediol linker.</jats:p>

収録刊行物

  • Chemistry Letters

    Chemistry Letters 33 (8), 1012-1013, 2004-07-12

    Oxford University Press (OUP)

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