Validated Spectrophotometric Methods for the Determination of Amiodarone Hydrochloride in Commercial Dosage Forms Using p-Chloranilic Acid and 2, 3-Dichloro-5, 6-dicyano-1, 4-benzoquinone

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抄録

Two simple, sensitive and economical spectrophotometric methods have been developed for the determination of amiodarone hydrochloride in pure form and commercial dosage form. These methods (A and B) are based on the reaction of amiodarone base as <i>n</i>-electron donor with <i>p</i>-chloranilic acid and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as π-acceptors to give highly colored complex species which absorb maximally at 535 and 570 nm, respectively. Beer’s law is obeyed in the concentration ranges 10.0 - 360.0 and 2.0 - 65.0 µg ml<sup>-1</sup> for methods A and B, respectively. Application of the proposed methods to commercial pharmaceutical tablets are presented.

収録刊行物

  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20(8), 1231-1235, 2004-08-10

    社団法人 日本分析化学会

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各種コード

  • NII論文ID(NAID)
    10013451121
  • NII書誌ID(NCID)
    AA10500785
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    09106340
  • NDL 記事登録ID
    7037928
  • NDL 雑誌分類
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL 請求記号
    Z54-F482
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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