Stanniocalcin-1 as a Novel Marker to Detect Minimal Residual Disease of Human Leukemia
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- TOHMIYA YASUO
- Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
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- KOIDE YOSHIO
- Department of Molecular Diagnostics, Tohoku University Graduate School of Medicine
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- FUJIMAKI SHINICHI
- Department of Molecular Diagnostics, Tohoku University Graduate School of Medicine
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- HARIGAE HIDEO
- Department of Molecular Diagnostics, Tohoku University Graduate School of Medicine
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- FUNATO TADAO
- Department of Molecular Diagnostics, Tohoku University Graduate School of Medicine
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- KAKU MITSUO
- Department of Molecular Diagnostics, Tohoku University Graduate School of Medicine
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- ISHII TOMONORI
- Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
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- MUNAKATA YASUHIKO
- Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
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- KAMEOKA JUNICHI
- Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
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- SASAKI TAKESHI
- Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
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Author(s)
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- TOHMIYA YASUO
- Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
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- KOIDE YOSHIO
- Department of Molecular Diagnostics, Tohoku University Graduate School of Medicine
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- FUJIMAKI SHINICHI
- Department of Molecular Diagnostics, Tohoku University Graduate School of Medicine
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- HARIGAE HIDEO
- Department of Molecular Diagnostics, Tohoku University Graduate School of Medicine
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- FUNATO TADAO
- Department of Molecular Diagnostics, Tohoku University Graduate School of Medicine
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- KAKU MITSUO
- Department of Molecular Diagnostics, Tohoku University Graduate School of Medicine
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- ISHII TOMONORI
- Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
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- MUNAKATA YASUHIKO
- Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
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- KAMEOKA JUNICHI
- Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
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- SASAKI TAKESHI
- Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine
Abstract
Stanniocalcin is a glycoprotein hormone that regulates the calcium level in fish. We found that mRNA of human stanniocalcin 1 (STC-1) is detectable in phytohemagglutinin-stimulated T cells and in most human leukemia cell lines, suggesting a role of STC-1 for cell proliferation. This finding prompts us to study the usefulness of STC-1 for monitoring acute leukemia. The levels of STC-1 transcripts increased in patients with acute leukemia at diagnosis and relapse, as judged by quantitative real-time RT-PCR. Levels of transcripts rapidly decreased to within the cut-off levels, when the blast numbers decreased with chemotherapy. Prolonged elevation of STC-1 levels after treatment was associated with a poor prognosis. All of 7 patients relapsed 1 to 4 months after they showed an elevated level of the transcripts in clinical remission. These results indicate that STC-1 is a novel marker for minimal residual disease of acute leukemia, and for an early diagnosis of relapse.
Journal
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 204(2), 125-133, 2004-10-01
Tohoku University Medical Press
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