Peripheral B lymphocyte tolerance

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著者

    • GAVIN Amanda
    • Department of Immunology, and Macromolecular Structure and Chemistry Program, The Scripps Research Institute
    • AIT-AZZOUZENE Djemel
    • Department of Immunology, and Macromolecular Structure and Chemistry Program, The Scripps Research Institute
    • MARTENSSON Annica
    • Department of Immunology, and Macromolecular Structure and Chemistry Program, The Scripps Research Institute
    • DUONG Bao
    • Department of Immunology, and Macromolecular Structure and Chemistry Program, The Scripps Research Institute
    • VERKOCZY Laurent
    • Department of Immunology, and Macromolecular Structure and Chemistry Program, The Scripps Research Institute
    • SKOG Jose Luis
    • Department of Immunology, and Macromolecular Structure and Chemistry Program, The Scripps Research Institute
    • SKOG Patrick
    • Department of Immunology, and Macromolecular Structure and Chemistry Program, The Scripps Research Institute
    • NEMAZEE David
    • Department of Immunology, and Macromolecular Structure and Chemistry Program, The Scripps Research Institute

抄録

This lecture discusses two interrelated topics, B cell tolerance in the peripheral immune system and BAFF. Using the 3-83 antibody transgenic mouse bred to mice carrying cognate antigen in the liver, we previously found that clonal elimination drastically reduced the precursor frequency of autoreactive cells. The consensus model to explain this tolerance is the 2-signal hypothesis, which proposes that in the absence of T cell help BCR stimulation is a negative signal for B cells. However, this model fails to explain how these same B cells can respond to T-independent type II (TI-2) antigens, raising the question of how they distinguish TI-2 antigens from multimeric self determinants. We propose that B cells use NK-like missing self recognition to provide the needed specificity, as foreign antigens are unlikely to carry self markers. The model has implications for the evolution of the immune system, B lymphocyte signaling, tissue specificity of autoimmunity, and microbial subversion of the immune system. Overexpression of the critical B cell survival cytokine BAFF/BLyS has been associated with autoimmunity. We have discovered a novel splice isoform that regulates BAFF activity and may play a role in limiting B cell activity. The novel form, called ΔBAFF, is able to heteromultimerize with normal BAFF and can suppress receptor binding and proteolytic release from the cell surface. Preliminary studies from transgenic mice overexpressing wild type or ΔBAFF are consistent with a possible regulatory role for ΔBAFF, raising the possibility that the relative expression levels of BAFF and ΔBAFF regulates tolerance.

収録刊行物

  • Keio journal of medicine

    Keio journal of medicine 53(3), 151-158, 2004-09-01

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10013563733
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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