YM-193221, a Novel Antifungal Antibiotic Produced by Pseudallescheria ellipsoidea

• KAMIGIRI KAZUMA

  Medicinal Resources Research, Lead Discovery Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

• TANAKA KOUICHI

  Medicinal Resources Research, Lead Discovery Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

• MATSUMOTO HISAO

  Analysis & Metabolism Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

• NAGAI KOJI

  Medicinal Resources Research, Lead Discovery Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

• WATANABE MASATO

  Medicinal Resources Research, Lead Discovery Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

• SUZUKI KENICHI

  Medicinal Resources Research, Lead Discovery Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

Abstract

A novel antifungal antibiotic, YM-193221, was found in the culture broth of a fungus, Pseudallescheria ellipsoidea. The structure of the antibiotic was determined through several spectroscopic experiments as 2-dimethylamino-1-(4-hydroxyphenyl)-8, 10-dimethyl-6-dodecene-3-one. YM-193221 exhibited potent antifungal activity against Candida albicans and also inhibited mannan synthesis in the yeast cell wall.

Journal

• The Journal of Antibiotics

  The Journal of Antibiotics 57 (9), 569-572, 2004

  JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

Keywords

• Drug Discovery
• Pharmacology

Details

• CRID: 1390001204154614656
• NII Article ID: 130003504201
• NII Article ID: 10013572461
• NII Book ID: AA0069330X
• DOI: 10.7164/antibiotics.57.569
• COI: 1:CAS:528:DC%2BD2cXotVylsL4%3D
• ISSN: 18811469
• ISSN: 00218820
• PubMed: 15580957
• Web Site: https://search.jamas.or.jp/link/ui/2006021680
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed