Apoptosis Inducement by Plant and Fungus Sphingoid Bases in Human Colon Cancer Cells

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In the present study, examination was made of the apoptosis-inducing activity of sphingoid bases from plant and fungus sphingolipids and the mechanisms involved. Sphingoid bases from maize and lactic yeast, <i>Kluyveromyces lactis</i> (<i>trans</i>-4, <i>trans</i>-8-sphingadienine, <i>trans</i>-4, <i>cis</i>-8-sphingadienine and 9-methyl-<i>trans</i>-4, <i>trans</i>-8-sphingadienine) were found to bring about apoptosis in Caco-2 human colon cancer cells. The apoptosis-inducing activity of <i>trans</i>-4, <i>cis</i>-8-sphingadienine and 9-methyl-<i>trans</i>-4, <i>trans</i>-8-sphingadienine was significantly higher than that of <i>trans</i>-4-sphingenine. In differentiated Caco-2 cells, the model for normal intestine cells, no apoptosis by sphingoid bases was noted to occur. The Caspase-3 inhibitor suppressed sphingoid base-induced apoptosis in Caco-2 cells, thus indicating activation of the caspase pathway to be related to sphingoid base-induced apoptosis in Caco-2 cells. Sphingoid bases from plants and fungi caused intracellular β-catenin content to decrease, as was also noted in the case of sphingosine and sphinganine from animal tissues. It would thus appear that sphingolipids in edible plants and fungi may be considered functional lipids and the apoptosis-inducing pathway by sphingoid bases may be related to signal transduction via β-catenin.<br>

収録刊行物

  • Journal of oleo science

    Journal of oleo science 53(10), 503-510, 2004-10-01

    Japan Oil Chemists' Society

参考文献:  37件中 1-37件 を表示

被引用文献:  5件中 1-5件 を表示

各種コード

  • NII論文ID(NAID)
    10013577364
  • NII書誌ID(NCID)
    AA11503337
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    13473352
  • NDL 記事登録ID
    7080760
  • NDL 雑誌分類
    ZP25(科学技術--化学・化学工業--油脂類)
  • NDL 請求記号
    Z54-J571
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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