Disodium Cromoglycate 吸入療法におけるβ刺激薬の発作時使用と定期使用の比較検討 COMPARISON BETWEEN ON-DEMAND USE AND REGULAR USE OF INHALED β STIMULANTS IN DISODIUM CROMOGLYCATE INHALATION THERAPY

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小児気管支喘息のDSCG定期吸入療法において, 吸入β刺激薬の発作時使用 (屯用群) と定期使用 (定期群) の有用性を比較するために, DSCG吸入療法を導入された喘息児を無作為に2群に分け, 56週間前方視的に経過観察した. 対象は, 途中吸入ステロイド薬を導入された4人を含む脱落者8人を除いて, 最終的には屯用群13人, 定期群9人であった.<br>β刺激薬の屯用での吸入回数は, 平均で屯用群190回, 定期群40回であったが, 吸入β刺激薬の使用総量は定期群87.8ml, 屯用群は29.9mlであった. 一方, 咳嗽日数は屯用群92.1日, 定期群49.6日と屯用群に多かったが, 発作点数は両群間に差はなかった. Dp-IgE値が低下したのは, 屯用群5人/12人, 定期群1人/8人であり, 有意差はなかった. 気道過敏性試験は屯用群3人, 定期群1人に施行したが, 両群に差はなかった.<br>屯用群では吸入β刺激薬の使用総量は少なかったが, 咳嗽日数が多かった. 喘息発作点数に差はなかった. 今回の検討では, DSCG吸入療法におけるβ刺激薬の発作時使用の有用性は明らかではなかった.

To compare the efficacy of the on-demand use with that of the regular use of β stimulants in Disodium Cromoglycate (DSCG) inhalation therapy, we randomly divided 30 patients into two groups (on-demand use group and regular use group), and compared the clinical courses prospectively for 56 weeks between these groups. Excluding 8 patients, including 2 in the on-demand use group and 2 in the regular use group into whom regular use of inhaled steroid was introduced, 13 patients in the on-demand use group and 9 in the regular use group were finally examined.<br>The frequency of on-demand inhalation of β stimulants was significantly higher in the on-demand use group (mean; 190 times) than in the regular use group (mean; 40 times), but the mean total amount of inhaled β stimulants was significantly less in the on-demand use group (mean; 29.9ml) than in the regular use group (mean; 87.8ml). The days when the patients had cough were on the average 92.1 days in the on-demand use group and 49.6 days in the regular use group, and the difference was statistically significant, but there was no difference in the asthmatic attacks between both groups. The ratio of patients who showed decreased levels of Dp-IgE was 5/12 in the on-demand use group and 1/8 in the regular use group. The bronchial hyperresponsiveness to acetylcholine was measured in 3 patients in the on-demand use group and in 1 in the regular use group, but there was no difference between them.<br>There was no difference in the asthmatic attacks between both groups, and the total amount of inhaled a stimulants was less, but the days when the patients had cough were more in the on-demand use group than in the regular use group. In this study, we could not show the efficacy of the on-demand use of β stimulants in DSCG inhalation therapy. Further studies with more subjects are necessary to assess the effectiveness of the on-demand use of β stimulants.

収録刊行物

  • 日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology

    日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology 18(3), 256-262, 2004-08-01

    日本小児アレルギー学会

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各種コード

  • NII論文ID(NAID)
    10013594105
  • NII書誌ID(NCID)
    AN10064415
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    09142649
  • データ提供元
    CJP書誌  J-STAGE 
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