免疫機能軽度低下を有する5症例に対する予防接種の検討  [in Japanese] EXAMINATION OF THE VACCINATIONS TO FIVE IMMUNO-COMPROMISED PATIENTS  [in Japanese]

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Abstract

免疫機能がどの程度まで保持されていれば予防接種を安全に行い得るのかは明らかでなく, この点に関しての明瞭な指針も無い. そこで著者らは, この指針作成の一助となる検討を行うことを目的として, 部分型 DiGeorge 症候群の3症例と乳児一過性低γ-globulin 血症の2症例に対し延べにして, BCGを4回, ポリオワクチンを3回, 麻疹ワクチンを3回, 風疹ワクチンを3回, および三種混合ワクチンを15回接種した. 予防接種前におけるCD3陽性細胞の最低レベルは3混ワクチンで33%, BCG・ポリオワクチンで47%, 麻疹・風疹ワクチンで49%であった. また, 予防接種前におけるCD4陽性細胞の最低レベルは, 3混ワクチンで18%, BCG・ポリオワクチンで25%, 麻疹・風疹ワクチンで29%であった. まず, PHAによるリンパ球幼若化反応が正常範囲であることがワクチン接種の前提である. そして, 今回の検討では重篤な副反応と考えられる症状の出現は認められなかったことから, CD3陽性細胞およびCD4陽性細胞が上記のレベル以上保持されている症例においては, ワクチン接種が可能であることが示唆された.

It is uncertain what level of immunofunction is needed for safe vaccinations. There is no definite guideline regarding this issue. Therefore, we inoculated 3 partial DiGeorge syndrome patients and 2 transient hypogammaglobulinemia of infancy patients; they were vaccinated with BCG vaccine (4 times), polio vaccine (3 times), measles vaccine (3 times), rubella vaccine (3 times) and diphtheria-purified pertussis-tetanus vaccine (15 times) in order to assist making the guideline for vaccinations to immunocompromised patients. The lowest level of CD3 positive T cells before the vaccinations was 49% in the case of measles/rubella vaccine, 47% in the case of BCG/polio vaccine and 33% in the case of diphtheria-purified pertussis-tetanus vaccine. In addition, the lowest level of CD4 positive T cells before the vaccinations was 29% in the case of measles/rubella vaccine, 25% in the case of BCG/polio vaccine and 18% in the case of diphtheria-purified pertussis-tetanus vaccine. Because no severe side effects were recognized after these vaccinations, it suggests safe to vaccinate the immunocompromised patients who keep the above mentioned levels of CD3 positive T cells and CD4 positive T cells.

Journal

  • Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology

    Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 18(2), 176-183, 2004-06-01

    THE JAPANESE SOCIETY OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY

References:  4

Codes

  • NII Article ID (NAID)
    10013594380
  • NII NACSIS-CAT ID (NCID)
    AN10064415
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    09142649
  • Data Source
    CJP  J-STAGE 
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