Bezafibrate-Induced Changes over Time in the Expression of Uncoupling Protein (UCP) mRNA in the Tissues: A Study in Spontaneously Type 2 Diabetic Rats with Visceral Obesity

• Mori Yutaka

  Department of Internal Medicine, National Hospital Organization, Utsunomiya National Hospital

• Tokutate Yoshiki

  Department of Discovery Research I, Kissei Pharmaceutical Co., Ltd.

• Oana Fumiki

  Department of Discovery Research I, Kissei Pharmaceutical Co., Ltd.

• Matsuzawa Akane

  Department of Discovery Research I, Kissei Pharmaceutical Co., Ltd.

• Akahane Satoshi

  Department of Discovery Research I, Kissei Pharmaceutical Co., Ltd.

• Tajima Naoko

  Division of Diabetes and Endocrinology, Department of Internal Medicine,The Jikei University School of Medicine

抄録

The effect of short-term bezafibrate (BF) administration over time on the expression of UCP mRNA in the tissues was examined in Otsuka Long Evans Tokushima Fatty (OLETF) rats. Eight-week-old rats were divided into a high-dose (100 mg/kg) BF group (n = 15), a low-dose (10 mg/kg) BF group (n = 15) and a control group (n = 15), and followed for 14 days. Feed intake by the high-dose BF group increased significantly between days 10 and 14 of administration. Triglyceride, free fatty acid, and T₄ levels decreased significantly in a dose-dependent manner in the high-dose BF group. Leptin and insulin levels significantly decreased on days 3 and 7. Throughout the study period, liver UCP2 mRNA increased in the high-dose BF group. On day 3 of BF administration, the levels of UCP2 mRNA expression in the skeletal muscles as well as UCP3 mRNA expression in the WAT were significantly increased in the high-dose BF group. PPAR-α mRNA significantly increased in the liver on day 3 of BF administration. We thus conclude that the PPAR-α-mediated effects of BF on the expression of liver UCP2 may be one of the factors that helped to decrease insulin levels.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 11 (4), 224-231, 2004

  一般社団法人 日本動脈硬化学会

キーワード

• Fibrate
• UCP-2
• PPAR-α
• Thyroid hormone

詳細情報

• CRID: 1390001204432924672
• NII論文ID: 10013608590
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.11.224
• ISSN: 18803873
• ISSN: 13403478
• PubMed: 15356383
• Web Site: https://www.jstage.jst.go.jp/article/jat/11/4/11_4_224/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2005077920
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可