In Vivo and In Vitro Positive Interference by Cefpirome in Measurement of Serum Creatinine by the Jaffe Method

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著者

    • KABURAKI Junichi
    • Department of Laboratory Medicine, Tokyo Electric Power Company Hospital
    • YAMADA Mitsuhiro
    • Department of Laboratory Medicine, Tokyo Electric Power Company Hospital
    • KONOSU Yumiko
    • Department of Laboratory Medicine, Tokyo Electric Power Company Hospital
    • IWASE Matsumi
    • Department of Laboratory Medicine, Tokyo Electric Power Company Hospital
    • UEHARA Sakae
    • Department of Laboratory Medicine, Tokyo Electric Power Company Hospital
    • KIKUCHI Hiromi
    • Department of Laboratory Medicine, Tokyo Electric Power Company Hospital

抄録

We report the case of an 81-year-old female patient with diverticulitis of the colon, whose symptoms were relieved by intravenous administration of cefpirome. However, her serum creatinine levels were falsely increased by the Jaffe method when serum samples were drawn after intravenous administration of cefpirome. The serum creatinine level in the same sample was within the normal range by the enzymatic method in the automated analyzer. <i>In vitro</i> experiment demonstrated dosedependent positive interference of the creatinine level with cefpirome. These results indicate that we should be aware of the positive interfering effect of cefpirome when we measure serum creatinine by the Jaffe method, and that the enzymatic method should be widely used to measure serum creatinine levels to eliminate false reactions due to certain chemicals.

収録刊行物

  • Keio journal of medicine

    Keio journal of medicine 48(2), 93-96, 1999-06-01

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10013620068
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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