Antitumor Effects of an Interferon-Loaded Silicone Formulation in Human Renal Cell Carcinoma in Nude Mice

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著者

    • MARUMO Ken
    • Department of Urology, School of Medicine, Keio University
    • MURAI Masaru
    • Department of Urology, School of Medicine, Keio University

抄録

Conventional therapy for renal cell carcinoma using interferon (IFN) has shown limited antitumor action. The IFN-loaded silicone formulation (IFN-SF) is a sustained-release formulation of human lymphoblastoid IFN, with a medical grade silicone elastomer used as the carrier material. We evaluated the antitumor effect of IFN-SF on human renal cell carcinoma cell line (KU-2) transplanted to nude mice. The treatment was started when the tumor nodules had grown 6 to 8 mm in diameter. IFN-SF, or an aqueous solution of IFN, was given by subcutaneous or peritumoral injection. Antitumor effects were evaluated according to tumor weights calculated as (long diameter)×(short diameter)<sup>2</sup>/2 in 7 groups consisting of 6 mice each. Serum IFN levels remained detectable up to 30 days after subcutaneous injection of IFN-SF. IFN-SF administered by the subcutaneous and peritumor route significantly inhibited growth of the tumor when compared with tumor growth in the untreated mice and mice treated with aqueous IFN solution. IFN-SF had equivalent inhibitory effects on tumor growth by peritumor and subcutaneous injection. Results indicated that the use of IFN-SF could reduce the frequency of injections and provide better treatment of patients with renal cell carcinoma because of its long-acting effect when it is used systemically.

収録刊行物

  • Keio journal of medicine

    Keio journal of medicine 48(4), 179-183, 1999-12-01

    The Keio Journal of Medicine

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各種コード

  • NII論文ID(NAID)
    10013620404
  • NII書誌ID(NCID)
    AA00710216
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00229717
  • データ提供元
    CJP書誌  J-STAGE 
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