UV DAMAGE TO THE EYE LENS : Further Results from Animal Model Studies : A review

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UV irradiation has the potential to induce the development of lens opacities. This has been demonstrated since long with animal experiments. Unfortunately these animal cataracts did not explain or elucidate the epidemiological observation that the frequency of human cataracts such as the so called senile cataract is remarkably higher in regions with increased cosmic UV irradiation or in the population being in close professional contact with UV-irradiation. The main problem was that the type of UV induced animal cataracts differs remarkably with respect to onset, localization of the opacity, size and its timely progression from the cataract classes observed in human. The research of the last 10 years comes to the conclusion that beside the direct (acute) damage as seen in animal studies due to high UV dosageswe have to realize a synor co-cataractogenic potential of UV irradiation even below the threshold dose which is able to accumulate in the lens and to initiate together with other risk factors (chronic damage) the opacification of the lens. The mechanism for the animal cataract and the human cataract (with an UV risk participation) are different. The epidemiological research about cataract frequency in different regions of the world have to take into account that UV irradiation -even below a threshold dose is a possible risk among the multifactorial pathogenesis of human cataract. <i>J Epidemiol</i>, 1999; 9 : S39-S47.

収録刊行物

  • Journal of epidemiology

    Journal of epidemiology 9(6), S39-S47, 1999-12

    日本疫学会

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各種コード

  • NII論文ID(NAID)
    10013628174
  • NII書誌ID(NCID)
    AA10952696
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    09175040
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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