Mutations in Cancer Genes of UV-Induced Skin Tumors of Hairless Mice

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著者

    • VAN KRANEN Henk J.
    • National Institute of Public Health and the Environment ; Laboratory of Health Effects Research, Department of Carcinogenesis, Mutagenesis and Genetics

抄録

Ultraviolet (UV) radiation is a very common carcinogen in our environment. Epidemiological data on the relationship between skin cancers and ambient solar UV radiation are very limited. Hairless mice provide the possibility to study the process of UV carcinogenesis in more detail. Experiments with this animal model have yielded quantitative data on how tumor development depends on dose, time and wavelength of the UV radiation. In addition, at the molecular level the interactions between UV, specific cancer genes-like the Ras oncogene family and the p53 tumor suppressor gene, together with the role of DNA repair in this process have been addressed recently. In wildtype hairless mice mutations in the p53 gene are clearly linked to UVB but not to UVA radiation. Furthermore, the p53 alterations seem to be essential early in tumor development. However, in Xpa-deficient mice this dependency on p53 alterations appeared to be different as is the tumor type induced by UVB. Research using genetically modified hairless mice should enable us to further unravel the mechanisms of UV-induced skin cancer. <i>J Epidemiol</i>, 1999; 9 : S58-S65.

収録刊行物

  • Journal of epidemiology

    Journal of epidemiology 9(6), S58-S65, 1999-12

    日本疫学会

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キーワード

各種コード

  • NII論文ID(NAID)
    10013628273
  • NII書誌ID(NCID)
    AA10952696
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09175040
  • データ提供元
    CJP書誌  CJP引用  J-STAGE 
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