HPLC Profile of Captopril Disulfide That Undergoes Reversible cis-trans Conversion among Three Isomers

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抄録

Peculiarly shaped chromatograms of some compounds that consist of <i>two</i> reversible isomers have been reported. Those of a compound that consists of <i>three</i> reversible isomers are described here. Because disulfide of captopril has two <i>cis-trans</i> convertible bonds, it exists in three forms of <i>cis-cis</i>, <i>cis-trans</i> and <i>trans</i>-<i>trans</i> isomers. The disulfide has produced various HPLC-UV profiles under various conditions, such as three split peaks, three peaks with bridging plateaus and one broad peak. The effect of the column temperature and the eluent flow rate on the profile was investigated and explained by interconversion among <i>three</i> isomers. A profile analysis could provide some kinetic constants of this reaction.

収録刊行物

  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20(10), 1395-1398, 2004-10-10

    社団法人 日本分析化学会

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各種コード

  • NII論文ID(NAID)
    10013657279
  • NII書誌ID(NCID)
    AA10500785
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09106340
  • NDL 記事登録ID
    7111346
  • NDL 雑誌分類
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL 請求記号
    Z54-F482
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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