Application of Difference NOE-pumping NMR Technique and Cold-Spray Ionization Mass Spectrometry to Identify a Ligand Binding with a Protein Receptor

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  • SEKI Hiroko
    Chemical Analysis Center, Chiba University CREST, Japan Science and Technology Agency (JST)
  • SEI Yoshihisa
    Chemical Analysis Center, Chiba University CREST, Japan Science and Technology Agency (JST)
  • SHIKII Kazuaki
    Chemical Analysis Center, Chiba University Analysis Research Department, Chemical Research Laboratories, Nissan Chemical Industries Ltd.
  • SHIMOTAKAHARA Sakurako
    School of Pharmacy, Tokyo University of Pharmacy and Life Science
  • UTSUMI Hiroaki
    NM Application & Research Group, Application & Research Center, Analytical Instruments Division, JEOL Ltd.
  • YAMAGUCHI Kentaro
    Chemical Analysis Center, Chiba University CREST, Japan Science and Technology Agency (JST)
  • TASHIRO Mitsuru
    Department of Chemistry, Faculty of Science, Tokyo Metropolitan University

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抄録

A difference diffusion-based NMR technique and cold-spray ionization mass spectrometry were employed as a solution-based approach for identifying a ligand binding with a protein receptor. The difference diffusion-based NMR technique, called difference NOE-pumping, can directly detect the ligand interacting with a protein receptor. This technique uses a simple pulse sequence and the diffusion filter can easily be optimized. The cold-spray ionization mass spectrometry (CSI-MS), a variant of electrospray ionization mass spectrometry (ESI-MS) operating at low temperature, has been applied to detect the ligand-receptor complex. The efficiency of these techniques for identifying binding ligands is demonstrated with the human serum albumin (HSA)-drug system.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 20 (10), 1467-1470, 2004

    社団法人 日本分析化学会

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