High Molecular Weight Form Insulin-like Growth Factor II-producing Mesenteric Sarcoma Causing Hypoglycemia

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著者

    • OTANI Yasukazu
    • Division of Internal Medicine and Surgery, Tokyo Metropolitan Fuchu Hospital
    • MINAMI Tomohito
    • Division of Internal Medicine and Surgery, Tokyo Metropolitan Fuchu Hospital
    • SHICHIRI Masayoshi
    • Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School
    • HIZUKA Naomi
    • Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University School of Medicine
    • AIBA Motohiko
    • Department of Surgical Pathology, Tokyo Women's Medical University Daini Hospital
    • HITARA Yukio
    • Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School

抄録

An 81-year-old woman presented with frequent episodes of hypoglycemia. Her serum level of insulin was normal, but her serum insulin-like growth factor (IGF)-II level was high. She was found to have a spindle cell sarcoma originated from the mesentery of the sigmoid colon, which was completely resected. Postoperatively, hypoglycemia ameliorated with concomitant reduction in serum IGF-II levels. Immunohistochemical study revealed positive immunostaining for IGF-II in tumor cells, and the abundant expression of IGF-II mRNA was demonstrated by RT-PCR. The presence of high molecular weight (HMW) form IGF-II in patient's serum was confirmed by immunoblotting. This is the first report of a patient with HMW form IGF-II-producing mesenteric sarcoma causing hypoglycemia.

収録刊行物

  • Internal medicine

    Internal medicine 43(10), 967-971, 2004-10-01

    一般社団法人 日本内科学会

参考文献:  20件中 1-20件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10013733559
  • NII書誌ID(NCID)
    AA10827774
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    09182918
  • NDL 記事登録ID
    7129734
  • NDL 雑誌分類
    ZS21(科学技術--医学--内科学)
  • NDL 請求記号
    Z53-M398
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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