High Molecular Weight Form Insulin-like Growth Factor II-producing Mesenteric Sarcoma Causing Hypoglycemia

• SATO Ryuji

  Division of Internal Medicine and Surgery, Tokyo Metropolitan Fuchu Hospital

• TSUJINO Motoyoshi

  Division of Internal Medicine and Surgery, Tokyo Metropolitan Fuchu Hospital

• NISHIDA Kenji

  Division of Internal Medicine and Surgery, Tokyo Metropolitan Fuchu Hospital

• OTANI Yasukazu

  Division of Internal Medicine and Surgery, Tokyo Metropolitan Fuchu Hospital

• MINAMI Tomohito

  Division of Internal Medicine and Surgery, Tokyo Metropolitan Fuchu Hospital

• SHICHIRI Masayoshi

  Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School

• HIZUKA Naomi

  Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University School of Medicine

• AIBA Motohiko

  Department of Surgical Pathology, Tokyo Women's Medical University Daini Hospital

• HIRATA Yukio

  Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School

Bibliographic Information

Other Title

• High Molecular Weight Form Insulin-like Growth Factor 2-producing Mesenteric Sarcoma Causing Hypoglycemia

Abstract

An 81-year-old woman presented with frequent episodes of hypoglycemia. Her serum level of insulin was normal, but her serum insulin-like growth factor (IGF)-II level was high. She was found to have a spindle cell sarcoma originated from the mesentery of the sigmoid colon, which was completely resected. Postoperatively, hypoglycemia ameliorated with concomitant reduction in serum IGF-II levels. Immunohistochemical study revealed positive immunostaining for IGF-II in tumor cells, and the abundant expression of IGF-II mRNA was demonstrated by RT-PCR. The presence of high molecular weight (HMW) form IGF-II in patient's serum was confirmed by immunoblotting. This is the first report of a patient with HMW form IGF-II-producing mesenteric sarcoma causing hypoglycemia.

Journal

• Internal Medicine

  Internal Medicine 43 (10), 967-971, 2004

  The Japanese Society of Internal Medicine

Keywords

• non-islet cell tumor hypoglycemia(NICTH)
• hypoglycemia
• insulin-like growth factor(IGF)-II
• mesenteric sarcoma

Details

• CRID: 1390001204866820864
• NII Article ID: 10013733559
• NII Book ID: AA10827774
• DOI: 10.2169/internalmedicine.43.967
• COI: 1:STN:280:DC%2BD2cngt1Siuw%3D%3D
• ISSN: 13497235
• ISSN: 09182918
• NDL BIB ID: 7129734
• PubMed: 15575249
• Web Site: http://id.ndl.go.jp/bib/7129734
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7129734
• Web Site: https://www.jstage.jst.go.jp/article/internalmedicine/43/10/43_10_967/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2005128484
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed