The Synthesis and Biological Activity of Pyranonaphthoquione Derivatives from <i>Streptomyces</i> sp. and Their Related Substances

• Shimbashi Akiko

  Department of Chemistry, Faculty of Science and Technology, Keio University

• Tsuchiya Ayako

  Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

• Imoto Masaya

  Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

• Nishiyama Shigeru

  Department of Chemistry, Faculty of Science and Technology, Keio University

書誌事項

タイトル別名

• The Synthesis and Biological Activity of Pyranonaphthoquione Derivatives from Streptomyces sp. and Their Related Substances
• Synthesis and Biological Activity of Pyranonaphthoquione Derivatives from Streptomyces sp and Their Related Substances

抄録

The total synthesis of a novel pyranonaphthoquinone (2) having Cdc25A phosphatase inhibitory activity is achieved. The key step in this synthetic pathway is the intramolecular Michael addition for construction of the pyran ring system. The inhibitory activity of several derivatives, readily obtained from synthetic intermediates of 2, is assessed. The resulting data indicates that the pyran ring moiety is not a crucial factor for the activity.

収録刊行物

• Bulletin of the Chemical Society of Japan

  Bulletin of the Chemical Society of Japan 77 (10), 1925-1930, 2004

  公益社団法人 日本化学会

キーワード

• General Chemistry

詳細情報

• CRID: 1390282679105862400
• NII論文ID: 130004151575
• NII論文ID: 10013737952
• NII書誌ID: AA00580132
• DOI: 10.1246/bcsj.77.1925
• ISSN: 13480634
• ISSN: 00092673
• NDL書誌ID: 7111906
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7111906
• Web Site: https://academic.oup.com/bcsj/article-pdf/77/10/1925/56264894/bcsj.77.1925.pdf
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可