TRANSFUSION-RELATED ACUTE LUNG INJURY CAUSED BY ANTI-HLA ANTIBODY IN A PATIENT WITH MYELODYSPLASTIC SYNDROME AND GASTRIC CANCER

• Shigematsu Akio

  Department of Internal Medicine, Sapporo Hokuyu Hospital Department of Hematology, Hokkaido University School of Medicine

• Yonezumi Masakatsu

  Department of Internal Medicine, Sapporo Hokuyu Hospital

• Imai Kiyotoshi

  Department of Internal Medicine, Sapporo Hokuyu Hospital

• Kobayashi Naoki

  Department of Internal Medicine, Sapporo Hokuyu Hospital

• Kiyama Yoshio

  Department of Internal Medicine, Sapporo Hokuyu Hospital

• Ogasawara Masahiro

  Department of Internal Medicine, Sapporo Hokuyu Hospital

• Higa Toshio

  Department of Internal Medicine, Sapporo Hokuyu Hospital

• Chino Hitomi

  Department of Blood Transfusion, Sapporo Hokuyu Hospital

• Miura Reiko

  Department of Blood Transfusion, Sapporo Hokuyu Hospital

• Sato Shinichiro

  Hokkaido Red Cross Blood Center

• Fujiwara Mitsuhiro

  Hokkaido Red Cross Blood Center

• Sekimoto Tatsuya

  Hokkaido Red Cross Blood Center

• Miyazaki Toru

  Hokkaido Red Cross Blood Center

• Ikeda Hisami

  Hokkaido Red Cross Blood Center

• Kasai Masaharu

  Department of Internal Medicine, Sapporo Hokuyu Hospital

Bibliographic Information

Other Title

• 抗ＨＬＡ抗体による輸血関連急性肺障害（Ｔｒａｎｓｆｕｓｉｏｎ‐Ｒｅｌａｔｅｄ　Ａｃｕｔｅ　Ｌｕｎｇ　Ｉｎｊｕｒｙ，　ＴＲＡＬＩ）を発症した胃癌合併骨髄異形成症候群

Abstract

We report a case of transfusion-related acute lung injury (TRALI) most likely caused by anti-HLA antibody in a patient with myelodysplastic syndrome and gastric cancer. The patient was a 76-year-old Japanese male diagnosed with myelodysplastic syndrome and gastric cancer who required transfusion due to bleeding from the gastric cancer. Just after platelet transfusion, he felt dyspnea and chill, followed by an increase in body temperature to 39°C and a decrease in arterial oxygen saturation to 68%. Chest x-ray showed bilateral pulmonary edema, suggesting the development of TRALI. Platelet transfusion was stopped and oxygen therapy and steroid pulse therapy were started. The patient recovered in a few days. Anti-HLA class II antibodies were detected In the donor serum, and cross-match testing between donor serum and recipient lymphocytes was strongly positive. We assume that the cause of this case was an immune reaction through anti-HLA class II antibodies.

Journal

• Journal of the Japan Society of Blood Transfusion

  Journal of the Japan Society of Blood Transfusion 50 (5), 720-725, 2004

  The Japan Society of Transfusion Medicine and Cell Therapy

Keywords

• transfusion-related acute lung injury (TRALI)
• anti-HLA class II antibody
• myelodysplastic syndrome
• gastric cancer
• steroid therapy

Details

• CRID: 1390282679884769408
• NII Article ID: 130003707093
• NII Article ID: 10013763667
• NII Book ID: AN00198368
• DOI: 10.3925/jjtc1958.50.720
• ISSN: 18838383
• ISSN: 05461448
• ISSN: http://id.crossref.org/issn/05461448
• Web Site: https://search.jamas.or.jp/link/ui/2005066257
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed