Survey of Vaccination and Viral Infections for Children with Severe Myoclonic Epilepsy in Infancy

• Tanabe Takuya

  Division of Pediatrics, Hirakata Municipal Hospital

• Awaya Yutaka

  Department of Pediatrics, Seibo International Catholic Hospital

• Matsuishi Toyojiro

  Department of Pediatrics and Child Health, Kurume University School of Medicine

• Nagai Toshisaburo

  Division of Child and Reproductive Health, Course of Health Science Graduate School of Medicine, Osaka University

• Yamamoto Katsuya

  Department of Pediatrics, Sendai City Hospital

• Kurihara Mana

  Department of Pediatrics, the Kanagawa Rehabilitation Center

• Iyoda Kuniaki

  Department of Pediatrics, Hiroshima City Hospital

• Maekawa Kihei

  Kanagawa University of Human Service

Bibliographic Information

Other Title

• 乳児重症ミオクロニーてんかん（ＳＭＥＩ）症例のワクチン接種状況調査

Abstract

A study group for establishment of a proposed immunization program for neurologically high risk children (Chief, Kihei Maekawa) sponsored by the Ministry of Health, Labour and Welfare of Japan is preparing a proposal for patients with epilepsy. Severe myoclonic eplepsy in infancy (SMEI) is an intractable epilepsy which often presents with status epilepticus and triggered by hyperthermia and viral infections. In this study we investigated the history of vaccination in children with SMEI to compare the risk of vaccination with that of natural contraction of infection. Fifty-eight patients with SMEI, aged from 2 to 25 years, were enrolled in this study. A total of 359 vaccines were given to these subjects. The vaccination rates were high for BCG (71%) and polio (1st; 71%, 2nd; 53%), and then fell gradually after the onset of SMEI (DPT-lst; 48%, DPT-2nd; 45%, DPT-3rd; 38%, DPT-4th; 24%, mumps; 21%, varicella; 19%, rubella 31%). However, the measles vaccine was given at a relatively high rate (55%) before the age of three. When patients suffered from measles, rubella, mumps or influenza, they had a high risk of severe neurological complications, such as convulsive status, disturbance of consciousness and encephalopathy. These complications were documented in 63% of all episodes of naturally contracted infections. This rate was significantly higher (p < 0.0001) than that associated with vaccination (7.2%). However, hyperthermia and convulsion developed more frequently (p 0.012) after measles vaccine was given, as compared to other vaccines. Thus, administration of these vaccines to patients with SMEI in conjunction with other preventive measures against seizure induced by hyperthermia, may meet the needs of their parents.

Journal

• NO TO HATATSU

  NO TO HATATSU 36 (4), 318-323, 2004

  THE JAPANESE SOCIETY OF CHILD NEUROLOGY

Keywords

• 乳児重症ミオクロニーてんかんSMEI
• 予防接種
• 副反応
• ハイリスク児
• ワクチン接種基準

Details

• CRID: 1390282679530457344
• NII Article ID: 130004183684
• NII Article ID: 10013764680
• NII Book ID: AN0020232X
• DOI: 10.11251/ojjscn1969.36.318
• ISSN: 18847668
• ISSN: 00290831
• PubMed: 15272616
• Web Site: https://search.jamas.or.jp/link/ui/2004272924
• Text Lang: ja
• Data Source:
  • JaLC
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed