散乱光粒子測定装置を用いた脳梗塞急性期の血小板自然凝集に関する検討

DOI 被引用文献1件 参考文献26件

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  • Measurement of spontaneous platelet aggregation in patients with acute cerebral infarction using laser-scattered light aggregometry

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Quantitative analysis of platelet aggregation is difficult, and the conditions of platelet aggregation in patients with acute cerebral infarction have not previously been examined in sufficient detail. We quantitated the spontaneous platelet aggregation (SPA) in patients with acute cerebral infarction using laser-scattered light aggregometry. The subjects comprised 98 patients with acute cerebral infarction. The subtype diagnoses included atherothrombotic infarction (ATI ; n = 45), lacunar infarction (LI ; n = 21) and cardioembolic in. farction (CE; n=32).The SPA was evaluated on days 1, 3, 7, 14 and 28 after the onset of cerebral infarction.The serum lipid, plasma glucose and diastolic blood pressure levels were relevant to the SPA after the onset of cerebral infarction. The maximum SPA was significantly increased in the patients with ATI and CE as compared to those with LI. No significant changes in SPA were recognized during the acute stage of cerebral infarction in cases of ATI or LI. The SPA on day 3 was significantly increased as compared to that on day 14 in CE. These findings suggest that activation of SPA differs among patients with different subtypes of cerebral infarction, and the SPA represents a useful marker of platelet activation.

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  • 脳卒中

    脳卒中 26 (2), 364-370, 2004

    一般社団法人 日本脳卒中学会

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