重回帰分析法による Enalapril 誘発咳嗽の患者背景因子に関する研究 Enalapril-induced Cough and Patient Characterisitcs : An Analysis by Multiple Regression Analysis

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The purpose of the present study was to investigate the relationship between enalapril-induced cough and patient characteristics such as age, sex, smoking, dosage of enalapril, history of allergy and combined use of β-blockers in outpatients of 27 hospitals, 9 clinics and 16 pharmacies in Japan. The data of this cross-sectional study obtained through interview with patients taking enalapril, were analyzed by multiple regression analysis.<BR>Of 3010 subjects, enalapril-induced coughing was found in 525 (17.4%). A significant correlation was found between cough and allergic factor, but the coefficient of determination was of low value (r<SUP>2</SUP>=0.0134, p<0.001). Furthermore, this odds ratio was 1.97 (95% CI, 1.60-2.43, p<0.001). These data suggest that allergic factors are related to enalapril-induced cough rather than background factors such as age, sex, smoking, dosage of enalapril and concomitant use of β-blockers.

収録刊行物

  • 臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

    臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 26(3), 737-742, 1995-09-30

    一般社団法人 日本臨床薬理学会

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各種コード

  • NII論文ID(NAID)
    10013831566
  • NII書誌ID(NCID)
    AN0025404X
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03881601
  • データ提供元
    CJP書誌  J-STAGE 
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