薬剤疫学(II)ニューキノロン剤(2) : ニューキノロン剤とAl^<3+>およびMg^<2+>を含有する薬剤との相互作用の薬剤疫学的検討 : ノルフロキサシンとオフロキサシンの比較 Pharmacoepidemiological Study (II) New Quinolones (2) : Drug-drug Interaction between the Quinolones (Norfloxacin, Ofloxacin) and Al^<3+> and/or Mg^<2+> Containing Antacids

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In a pharmacoepidemiological study, the response to norfloxacin and ofloxacin (duration of treatment and total dose prescribed) was analyzed in order to determine whether norfloxacin and ofloxacin in combination with metal cation-containing prepara tions have an effect on the outcome of treatment.<BR>The treatment duration and total dose prescribed were significantly greater (p<0.005, respectively ; using the Mann-Whitney test) in the patients given norfloxacin in combination with metal cation-containing agents than in those on monotherapy. However, the effects ofloxacin showed no change by combination administration with drugs containing magnesium and/or aluminum.

収録刊行物

  • 臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

    臨床薬理 = JAPANESE JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS 26(4), 867-873, 1995-12-31

    The Japanese Society of Clinical Pharmacology and Therapeutics

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各種コード

  • NII論文ID(NAID)
    10013831812
  • NII書誌ID(NCID)
    AN0025404X
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03881601
  • データ提供元
    CJP書誌  J-STAGE 
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