The Effects of Functional Electrical Stimulation on Intrinsic Laryngeal Muscle Atrophy after Denervation

DOI IR 6 Citations 13 References
  • Katada Akihiro
    Department of Otolaryngology Head and Neck Surgery, Asahikawa Medical College
  • Nonaka Satoshi
    Department of Otolaryngology Head and Neck Surgery, Asahikawa Medical College
  • Kunibe Isamu
    Department of Otolaryngology Head and Neck Surgery, Asahikawa Medical College
  • Adachi Masaaki
    Department of Otolaryngology Head and Neck Surgery, Asahikawa Medical College
  • Shigyo Hiroshi
    Department of Otolaryngology Head and Neck Surgery, Asahikawa Medical College
  • Imada Masanobu
    Department of Otolaryngology Head and Neck Surgery, Asahikawa Medical College
  • Hayashi Tatsuya
    Department of Otolaryngology Head and Neck Surgery, Asahikawa Medical College
  • Harabuchi Yasuaki
    Department of Otolaryngology Head and Neck Surgery, Asahikawa Medical College

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  • 脱神経後の内喉頭筋萎縮に対する機能的電気刺激の効果

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Abstract

In this study, we estimated whether functional electrical stimulation (FES) was capable of preventing atrophy of the intrinsic laryngeal muscles caused by denervation of the recurrent laryngeal nerve (RLN).<br>We used 18 adult rats for this study. After resection of the left RLN, a pair of stimulation electrodes was placed in the left paralyzed thyroarytenoid (TA) muscle. FES, with 2 mA rectangular pulses of 0.2 ms duration at 2 Hz lasting for 1 h, was delivered to the paralyzed TA muscle once in 2 days. After the observation periods, frontal sections of the larynx 8 μm in thickness were prepared. We analyzed the differences in the area of the TA muscle, the area of the TA muscle fiber and the density of the TA muscle fiber after denervation with and without FES.<br>In the animals without FES, a decrease in the area of the TA muscle and muscle fiber and an increase in the density of the TA muscle fiber were observed as denervative muscle atrophy. In the animals with FES, the same changes were observed until 2 weeks after the resection of the recurrent laryngeal nerve. However, the area of the TA muscle, the area of the TA muscle fiber and the density of the TA muscle fiber recovered and reached the same levels as the intact side after 6-8 weeks in the animals with FES.<br>From the results of this study, we confirmed that FES prevented atrophy of the paralyzed intrinsic laryngeal muscle. These results suggest the possibility that FES can reduce the impairment in laryngeal function induced by recurrent laryngeal nerve palsy.

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