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- 安部 茂
- 帝京大学医真菌研究センター
書誌事項
- タイトル別名
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- Development of Murine Experimental Model for Candidiasis and Its Application
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抄録
Candida albicans is a major cause of oral and esophageal infections in elder persons with poor oral hygiene and immuncompromised patients with hyposalivation, diabetes mellitus, prolonged use of antibiotics or immunosuppressive drugs. Oral thrush is a common form of oropharyngeal candidiasis whose clinical features consist of white patches appearing as discrete lesions on the buccal mucosa, throat, tongue, and gum linings that develop into confluent pseudomembranes resembling milk curds. We recently reported a simple murine model of thrush-type oral candidiasis that mimics the natural infectionin humans and is useful for both symptomatological and mycological evaluation of the responsiveness to antifungal treatments. By using this oral candidiasis model, protective activities of oral administration of several types of herbal preparations such as teatree oil, clove preparation and bovine lactoferrin were clarified. The mechanisms of protective actions of lactoferrin against oral candidiasis were particularly elucidated to include augmentation of T-cell activities of lesional lymphoid tissues. More recent studies suggested that saliva from healthy persons also shows a protective action for this murine oral candidiasis model.
収録刊行物
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- 日本医真菌学会雑誌
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日本医真菌学会雑誌 45 (4), 227-231, 2004
日本医真菌学会
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詳細情報 詳細情報について
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- CRID
- 1390001204212638080
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- NII論文ID
- 130003672099
- 10014022688
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- NII書誌ID
- AN10166867
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- ISSN
- 18820476
- 09164804
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- PubMed
- 15550920
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可