Two New Biologically Active Illudane Sesquiterpenes from the Mycelial Cultures of Panaeolus retirugis

• MA WENZHE

  South China Botanical Garden, Chinese Academy of Sciences

• HUANG YICUN

  Institute of Microbiology, Chinese Academy of Sciences

• LIN LIDONG

  South China Botanical Garden, Chinese Academy of Sciences

• ZHU XIAOFENG

  Cancer Institute, Cancer Center, Sun Yat-sen University

• CHEN YIZHU

  South China Botanical Garden, Chinese Academy of Sciences

• XU HANHONG

  Key Lab. of Pesticides and Chemical Biology, Ministry of Education

• WEI XIAOYI

  South China Botanical Garden, Chinese Academy of Sciences

抄録

Two new illudane sesquiterpenes, paneolic acid and paneolilludinic acid, along with a known antibiotic diterpene, pleuromutilin, were isolated from the mycelial solid cultures of Panaeolus retirugis. Their structures were elucidated on the basis of spectroscopic analysis. Both compounds exhibited antibacterial activity against Staphylococcus aureus, and paneolic acid showed cytotoxicity to HL60 cell with an IC₅₀ of 18.9μg/ml.

収録刊行物

• The Journal of Antibiotics

  The Journal of Antibiotics 57 (11), 721-725, 2004

  公益財団法人 日本感染症医薬品協会

キーワード

• Drug Discovery
• Pharmacology

詳細情報

• CRID: 1390001204152596864
• NII論文ID: 130003410522
• NII論文ID: 10014024029
• NII書誌ID: AA0069330X
• DOI: 10.7164/antibiotics.57.721
• COI: 1:CAS:528:DC%2BD2cXhtVGltr%2FI
• ISSN: 18811469
• ISSN: 00218820
• Web Site: https://search.jamas.or.jp/link/ui/2006149504
• 本文言語コード: en
• データソース種別:
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