Regulatory T 細胞と炎症性腸疾患  [in Japanese] Regulatory T cells and inflammatory bowel diseases  [in Japanese]

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Author(s)

    • 金井 隆典 KANAI Takanori
    • 東京医科歯科大学医歯学総合大学院消化器病態学 Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University
    • 渡辺 守 WATANABE Mamoru
    • 東京医科歯科大学医歯学総合大学院消化器病態学 Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University

Abstract

炎症性腸疾患 (潰瘍性大腸炎とクローン病) は, いまだ原因は不明であり, 近年, 本邦において, 罹患数の増加傾向が問題となっている. 原因として, 免疫学的異常, 遺伝学的異常, 環境因子などがあげられるが, 複数の原因が複雑に絡み合いながら病態を形成しているものと想定されている. こうした中, 自己免疫機序として, 制御性T細胞 (Regulatory T細胞) の存在が近年注目を集めている. 本総説では, 炎症性腸疾患を腸内細菌を含む自己抗原に対する過剰反応と捉え, 制御性T細胞の役割について概説する.

Crohn’s disease and ulcerative colitis are two major forms of human inflammatory bowel diseases (IBD). Their etiology is unknown, but increasing evidence indicate that immune mechanisms play an important role. It is well known that immune responses in the intestine remain in a state of controlled inflammation, suggesting that not only active suppression by regulatory T (T<SUB>R</SUB>) cells plays an important role in the normal intestinal homeostasis, but also its dysregulation leads to the development of IBD. This article reviews the unique aspects of T<SUB>R</SUB> cells and discuss how these control the intestinal homeostasis.

Journal

  • Japanese Journal of Clinical Immunology

    Japanese Journal of Clinical Immunology 27(5), 302-308, 2004-10-31

    The Japan Society for Clinical Immunology

References:  39

Codes

  • NII Article ID (NAID)
    10014046140
  • NII NACSIS-CAT ID (NCID)
    AN00357971
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    09114300
  • Data Source
    CJP  J-STAGE 
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