Relationship between diseases and cellular signaling abnormality

• Kitajima Isao

  Department of Laboratory Medicine Molecular Pathology, Toyama Medical and Pharmaceutical University

Bibliographic Information

Other Title

• シグナル伝達系異常と疾患

Abstract

First, I introduced briefly signal transduction in intact cells. The following were discussed: 1) The role of tyrosine kinase, which responds to extracellular stimulation. 2) The role of GTP protein, which transmits a signal from membrane receptor to cytoplasmic protein as a second messenger. 3) The role of MAP kinase signal, which participates in pathways important for cell proliferation and differentiation and apoptosis. Next, the relationship between diseases including cancer and intracellular signaling transduction abnormality was described. The importance of transcriptional factors that integrate cellular siginaling was shown and the relationship between some diseases and transcriptional control abnormality of nuclear factor-kappa B (NFκB) was focused on. It was found that constitutive NF-κB activation in cancer cells affects the antiapoptotic function, and that TNF-α or lipopolysaccharide (LPS) induced hyperactivation of NF-κB is the crucial etiology of the systemic inflammatory reaction syndrome (SIRS).

Journal

• Japanese Journal of Clinical Chemistry

  Japanese Journal of Clinical Chemistry 33 (3-4), 163-176, 2004

  Japan Society of Clinical Chemistry

Keywords

• gene expression regulation
• transcriptional factor
• NF-κB
• cancer
• apoptosis
• inflammation

Details

• CRID: 1390282679888064512
• NII Article ID: 130003357228
• NII Article ID: 10014070678
• NII Book ID: AN00252758
• DOI: 10.14921/jscc1971b.33.3-4_163
• ISSN: 21874077
• ISSN: 03705633
• Web Site: https://search.jamas.or.jp/link/ui/2005085462
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed