Malfunction of Vascular Control in Lifestyle-Related Diseases: Distribution of Adrenomedullin-Containing Perivascular Nerves and Its Alteration in Hypertension
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- Hobara Narumi
- Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Okayama University
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- Nakamura Arisa
- Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Okayama University
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- Goda Mitsuhiro
- Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Okayama University
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- Kawasaki Hiromu
- Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Okayama University
Bibliographic Information
- Other Title
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- Distribution of Adrenomedullin-Containing Perivascular Nerves and Its Alteration in Hypertension
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Abstract
The distribution and characteristics of adrenomedullin (AM)-containing perivascular nerves in the rat mesenteric artery were investigated using immunohistochemical techniques. Many fibers containing AM-like immunoreactivity (LI) were observed in the adventitia of mesenteric arteries, which were densely innervated by calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-LI fibers. AM-LI, CGRP-LI, and NPY-LI fibers were abolished by cold storage denervation. Capsaicin pretreatment abolished AM-LI and NPY-LI fibers but not NPY-LI fibers. NPY-LI fibers but not AM-LI and CGRP-LI fibers disappeared after treatment with 6-hydroxydopamine. There were many AM-LI positive cells in the dorsal root ganglia, where AM mRNA was detected. In a double immunofluorescence study, AM-LI was found in CGRP-LI fibers, although some fibers contained AM-LI alone. The density of AM-LI fibers was lower in SHR than in WKY mesenteric arteries. These results suggest that the mesenteric artery is innervated by AM-containing perivascular nerves and AM may have a neurotransmitter role in the regulation of vascular tone.<br>
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 96 (4), 391-394, 2004
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001205175304448
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- NII Article ID
- 10014075582
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 7195693
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- PubMed
- 15599094
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed