遷移金属触媒を用いるハロゲン化アルキル類と有機金属試薬とのクロスカップリング反応

• 寺尾 潤

  大阪大学大学院工学研究科

• 神戸 宣明

  大阪大学大学院工学研究科

書誌事項

タイトル別名

• Cross-coupling Reaction of Alkyl Halides with Organometallic Reagents Using Transition-Metal Catalysts
• センイ キンゾク ショクバイ オ モチイル ハロゲンカ アルキルルイ ト ユウキ キンゾク シヤク ト ノ クロスカップリング ハンノウ

抄録

Cross-coupling reaction of organic halides with main group organometallic reagents has now become one of the most practical and reliable methods for constructing C-C bonds in organic synthesis. During the last three decades numbers of such reactions using organic halides bearing C (sp²) -X bond have been developed by the aid of transition-metal catalysts, especially Pd and Ni. On the other hand, the use of alkyl halides in transition-metal catalyzed cross-coupling reaction had not well been developed until quite recently. This is probably due to the low reactivities of alkyl halides toward oxidative addition and also to undesirable facile β-elimination from alkylmetal intermediates. Since several years ago, however, some significant methodological evolutions to overcome these difficulties have been achieved by tuning up the ligands and/or constructing novel catalytic systems based on new mechanisms. This review article summarizes recent progress in transition metal-catalyzed cross-coupling reaction of alkyl halides with organometallic reagents.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 62 (12), 1192-1204, 2004

  公益社団法人 有機合成化学協会

キーワード

• cross-coupling reaction
• alkyl halides
• organometallic reagents
• C-C bond formation
• transition metal catalysts
• Grignard reagents

詳細情報

• CRID: 1390001205313177856
• NII論文ID: 10014119542
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.62.1192
• COI: 1:CAS:528:DC%2BD2cXhtV2qurnL
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 7179495
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7179495
• 本文言語コード: ja
• データソース種別:
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  • NDL
  • Crossref
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  • KAKEN
• 抄録ライセンスフラグ: 使用不可