Forefront of Na+/Ca2+ Exchanger Studies: Regulation Kinetics of Na+/Ca2+ Exchangers

• Matsuoka Satoshi

  Department of Physiology and Biophysics, Kyoto University Graduate School of Medicine

Bibliographic Information

Other Title

• Regulation Kinetics of Na〔+〕/Ca〔2+〕 Exchangers
• Regulation Kinetics of Na Ca 2 Exchangers

Abstract

Five isoforms of Na⁺/Ca²⁺ exchanger have been identified: NCX1, NCX2, NCX3, NCX-SQ1, and CALX. In all of the exchangers, the Na⁺/Ca²⁺ exchange current, which was recorded in inside-out membrane patches, was regulated by cytoplasmic Ca²⁺. However, the mode of regulation is different among the exchangers. NCX1, NCX2, and NCX-SQ1 are positively regulated by cytoplasmic Ca²⁺, but CALX is negatively regulated. NCX3 apparently has both positive and negative regulation mechanisms. In this review, I briefly summarize the Ca²⁺-dependent regulation mechanisms of the exchangers.<br>

Journal

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 96 (1), 12-14, 2004

  The Japanese Pharmacological Society

Keywords

• Na⁺/Ca²⁺ exchanger (NCX)
• transporter
• regulation
• patch clamp

Details

• CRID: 1390282680151864064
• NII Article ID: 10014166085
• NII Article ID: 130000074346
• NII Book ID: AA11806667
• DOI: 10.1254/jphs.fmj04002x2
• ISSN: 13478648
• ISSN: 13478613
• NDL BIB ID: 7084149
• PubMed: 15351790
• Web Site: http://id.ndl.go.jp/bib/7084149
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7084149
• Web Site: https://search.jamas.or.jp/link/ui/2006100118
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed