Gene Expression Profile in Experimental Mesangial Proliferative Glomerulonephritis

• Izumi Yasukatsu

  Department of Pharmacology, Osaka City University Graduate School of Medical Science

• Izumiya Yasuhiro

  Department of Pharmacology, Osaka City University Graduate School of Medical Science

• Shiota Masayuki

  Department of Pharmacology, Osaka City University Graduate School of Medical Science

• Yukimura Tokihito

  Department of Pharmacology, Osaka City University Graduate School of Medical Science

• Shiojima Satoshi

  Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sciences

• Yamada Masateru

  Pharmaceutical Research Laboratories, Toray Industries, Inc.

• Kadowaki Tadashi

  Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sciences

• Katsuma Susumu

  Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sciences

• Hirasawa Akira

  Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sciences

• Tsujimoto Gozoh

  Department of Genomic Drug Discovery Science, Kyoto University Graduate School of Pharmaceutical Sciences

• Iwao Hiroshi

  Department of Pharmacology, Osaka City University Graduate School of Medical Science

Abstract

We analyzed gene expression in rat anti-Thy1 antibody-induced glomerulonephritis by using the cDNA microarray method. Ninety-seven genes that differed by more than 1.5-fold intensity in comparison with the controls were selected. Cluster analysis showed that the expression of genes associated with inflammation reached maximum levels at 24 h, while genes involved in the development of fibrosis increased at 7 days after injection. Microarray analysis of animal disease models may be a powerful approach for understanding the gene expression programs that underlie these disorders.<br>

Journal

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 96 (1), 91-94, 2004

  The Japanese Pharmacological Society

Keywords

• cDNA microarray
• nephritis
• gene expression

Details

• CRID: 1390282680151826688
• NII Article ID: 10014166433
• NII Book ID: AA11806667
• DOI: 10.1254/jphs.rc0040012
• ISSN: 13478648
• ISSN: 13478613
• NDL BIB ID: 7084312
• PubMed: 15351794
• Web Site: http://id.ndl.go.jp/bib/7084312
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7084312
• Web Site: https://search.jamas.or.jp/link/ui/2006100129
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed