Convergence and Divergence, a Concept for Explaining Drug Actions
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- Watanabe Takehiko
- Department of Pharmacology, Tohoku University Graduate School of Medicine
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- Kamisaki Yoshinori
- Department of Pharmacology, Osaka University Graduate School of Dentistry
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- Timmerman Henk
- Department of Pharmacochemistry, Vrije Universiteit
Bibliographic Information
- Other Title
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- Current Perspective: Convergence and Divergence, a Concept for Explaining Drug Actions
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Abstract
For the teaching and/or learning about drug actions and for the discovery and development of new drugs, it is important to understand how drugs act on living bodies. So far, there has been no clear description on the general principle of drug action in pharmacology textbooks. We propose two principles to depict the action mechanism of drugs. The first is that most, if not all, drugs act on proteins at the molecular level, that is, enzymes, receptors, ion channels, and transporters. The second is that a drug may cause divergent or convergent responses, resulting in changes of a physiological or pathological function of the human body. The concept of divergence and convergence can be used to explain the complex individuality of drug actions.<br>
Journal
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- Journal of Pharmacological Sciences
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Journal of Pharmacological Sciences 96 (2), 95-100, 2004
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001205175613056
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- NII Article ID
- 10014166444
- 130000074183
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- NII Book ID
- AA11806667
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- ISSN
- 13478648
- 13478613
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- NDL BIB ID
- 7120571
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- PubMed
- 15492469
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed